446: Calcium Alkali Thiazide Syndrome

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The calcium-alkali syndrome.

The milk-alkali syndrome was a common cause of hypercalcemia, metabolic alkalosis, and renal failure in the early 20th century. It was caused by the ingestion of large quantities of milk and absorbable alkali to treat peptic ulcer disease. The syndrome virtually vanished after introduction of histamine-2 blockers and proton pump inhibitors. More recently, a similar condition called the calcium-...

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Calcium-alkali syndrome is characterized by hypercalcemia, renal injury and metabolic alkalosis. Calcium-alkali syndrome caused by calcium carbonate and vitamin D has been increasing in association with their growing use for the treatment and prevention of osteoporosis. Renal injury is the most critical factor determining the severity and prognosis of this syndrome. This review focuses on the m...

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Calcium-Alkali Syndrome in the Modern Era

The ingestion of calcium, along with alkali, results in a well-described triad of hypercalcemia, metabolic alkalosis, and renal insufficiency. Over time, the epidemiology and root cause of the syndrome have shifted, such that the disorder, originally called the milk-alkali syndrome, is now better described as the calcium-alkali syndrome. The calcium-alkali syndrome is an important cause of morb...

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Milk alkali syndrome and the dynamics of calcium homeostasis.

I ntensive treatment with calcium-containing antacids and milk first was used in the early 20th century for the treatment of peptic ulcer disease and sometimes was associated with toxicity, eventually known as the milk alkali syndrome. Despite the introduction of H2 blockers and proton pump inhibitors for the treatment of peptic ulcer disease, the milk alkali syndrome continues to occur but is ...

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Milk alkali syndrome.

The milk alkali syndrome was more commonly seen when milk and absorbable alkalis were the mainstays of treatment of symptoms due to acidrelated upper gastro-intestinal disease. The syndrome became rarer after the introduction of the non-absorbable alkalis and H2 receptor antagonists but it did not disappear altogether and should always be suspected when patients present with hypercalcaemia, ren...

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ژورنال

عنوان ژورنال: Critical Care Medicine

سال: 2020

ISSN: 0090-3493

DOI: 10.1097/01.ccm.0000727672.35448.9b